With Eclipse the Pandora issues happen much less than they do on the stock ROM. They do still occur though. I don't think I have ever had a skip or pop using Pandora, but I also tend to leave they phone alone other than an occasional upvote etc. My main issue with Pandora on Android has been that it just stops playing a song and cuts to the next one or an ad. If you google the issue it seems to be a common theme among Android phones and Pandora.
All that said there is a new version of Pandora on the market that mentions fixing an out of memory condition, so maybe that will help. I have tried and old 1.3 version that was skinned and did not display ads, butt that would also skip for me. If you find a bulletproof solution, let me know
